Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides

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dc.creator Vera, Berta es_ES
dc.creator Santa Cruz, Silvia es_ES
dc.creator Magnarelli, Gladis es_ES
dc.date 2012-04
dc.date.accessioned 2019-05-30T18:01:34Z
dc.date.available 2019-05-30T18:01:34Z
dc.identifier https://www.journals.elsevier.com/reproductive-toxicology es_ES
dc.identifier.issn 0890-6238 es_ES
dc.identifier.uri http://rdi.uncoma.edu.ar:8080/handle/123456789/15224
dc.description.abstract Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.
dc.format application/pdf es_ES
dc.format.extent pp. 402-407 es_ES
dc.language en en
dc.publisher Elsevier es_ES
dc.publisher Board es_ES
dc.rights Atribución-NoComercial-SinDerivadas 2.5 Argentina *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ *
dc.source ReproductiveToxicology 34 (2012) es_ES
dc.subject Organophosphate pesticides es_ES
dc.subject Carboxylesterase es_ES
dc.subject Lipid composition es_ES
dc.subject Placenta es_ES
dc.subject.other Ciencias de la Tierra y Medio Ambiente es_ES
dc.subject.other Ciencias Biomédicas es_ES
dc.title Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides es_ES
dc.type Articulo es
dc.type article eu
dc.type acceptedVersion eu
dc.description.fil Fil: Vera, Berta. Universidad Nacional del Comahue. Facultad de Ciencias Médicas; Argentina. es_ES
dc.description.fil Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad de Ingeniería. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte (IDEPA). CONICET; Argentina. es_ES


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